Quechua. Quechua, also called Runa simi in Southern Quechua, is an indigenous language family that originated in central Peru and thereafter spread to other countries of the Andes. Derived from a common ancestral "Proto-Quechua" language, it is the most widely spoken pre-Columbian language family of the Americas, with an estimated 8???10 million speakers in 2004, and just under 7 million from the most recent census data available up to 2011. Approximately 13.9% of Peruvians speak a Quechua language.